Downstream Production Manager
Downstream Production Manager – Peptide Manufacturing
Location: Onsite - Torrance, CA | Employment Type: Full-Time
Lead the critical final steps of peptide manufacturing! We’re seeking a Downstream Production Manager to oversee GMP operations focused on purification, chromatography, concentration, lyophilization, and final API handling. This strategic leadership role ensures safety, compliance, and efficiency while driving continuous improvement and capacity planning.
What You’ll Do:
- Direct downstream production teams and workflows.
- Develop and manage production schedules for purification and lyophilization.
- Implement process improvements and Lean principles to optimize yield and throughput.
- Ensure GMP compliance and accurate documentation.
- Foster a strong safety culture and lead workforce development.
What We’re Looking For:
- Bachelor’s degree in a science-related field (Master’s or PhD preferred).
- 5+ years of leadership experience in pharmaceutical manufacturing; peptide experience strongly preferred.
- Expertise in purification, chromatography, and lyophilization under GMP.
- Strong leadership, problem-solving, and strategic planning skills.
Why Join Us? Be part of a high-impact team delivering life-changing peptide APIs with precision and innovation.
Salary: $130k - $145k / year
We are an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity or expression, pregnancy, age, national origin, disability status, genetic information, protected veteran status, or any other characteristic protected by law.
- Department
- Production
- Locations
- Torrance, CA
Torrance, CA
Perks & Benefits
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Paid Holidays (13 Holidays)
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Paid Vacation Leave
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Paid Sick Leave
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Birthday Off
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Tuition Reimbursement Program
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Basic Life Policy & AD&D
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401K (6%Matching)
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Health Insurance (Medical, Dental, Vision)
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Student Debt Reduction Program
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Fresh Fruit Program
Our Values
INNOVATION
- We are curious and explore new ways.
- We are ambitious and find solutions.
EXCELLENCE
- We have a strong technical knowledge and we deliver results.
- We deliver quality in everything we do.
TRUST
- We believe in teamwork and collaboration.
- We lead by example and accept responsibility.
About PolyPeptide US
PolyPeptide is a specialized Contract Development & Manufacturing Organization (CDMO) for peptide and oligonucleotide-based active pharmaceutical ingredients (API). By supporting its customers mainly in pharma and biotech, it contributes to the health of millions of patients across the world.
PolyPeptide serves a fast-growing market, offering products and services from pre-clinical through to commercial stages. Its broad portfolio reflects the opportunities in drug therapies across areas and with a large exposure to metabolic diseases, including GLP-1.
Dating back to 1952, PolyPeptide today runs a global manufacturing network in Europe, the U.S. and India.
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